Дисприн индийские таблетки инструкция по применению

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Ацетилсалициловая кислота+Лимонная кислота+Кальция карбонат

Ацетилсалициловая кислота+Лимонная кислота+Кальция карбонат.

Противовоспалительные средства — производные салициловой кислоты

Показания к применению Дисприн таблетки 500мг

Ревматизм, ревматоидный артрит, инфекционно-аллергический миокардит; лихорадочный синдром при инфекционно-воспалительных заболеваниях, болевой синдром, головная боль, мигрень, зубная боль, невралгия, миалгия, артралгия, альгодисменорея, тромбоз и тромбоэмболия (профилактика), инфаркт миокарда (вторичная профилактика), транзиторные ишемические нарушения мозгового кровообращения.

Способ применения и дозировка Дисприн таблетки 500мг

Внутрь. Взрослым — в разовой дозе 1-2 таблетки; максимальная суточная доза — 8 таблеток. Детям — разовая доза 0.5-1.5 таблетки; максимальная суточная доза — 4 таблетки.

Противопоказания Дисприн таблетки 500мг

Гиперчувствительность к салицилатам и др. НПВП, язвенная болезнь желудка и 12-перстной кишки (в стадии обострения), желудочно-кишечное кровотечение, «аспириновая» астма, гемофилия, геморрагический диатез, гипопротромбинемия, портальная гипертензия, авитаминоз K, тяжелая почечная и/или печеночная недостаточность, беременность (I и III триместры), период лактации, дефицит глюкозо-6-фосфатдегидрогеназы, повышенная склонность к кровотечениям, детский возраст до 15 лет .C осторожностью: подагра, заболевания печени, одновременное применение др. НПВП или урикозурических ЛС, антикоагулянтов непрямого действия, тиклопидина, гепарина, интерферона альфа, метотрексата.

Фармакологическое действие

Комбинированный препарат, действие которого обусловлено входящими в его состав компонентами; оказывает противовоспалительное, жаропонижающее, антиагрегантное, анальгезирующее действие.

Побочное действие Дисприн таблетки 500мг

Тошнота, снижение аппетита, гастралгия, диарея, эрозивно-язвенные поражения ЖКТ, кровотечения в ЖКТ, аллергические реакции, печеночная и/или почечная недостаточность, тромбоцитопения, анемия, лейкопения. При длительном применении — головокружение, головная боль, нарушения зрения, шум в ушах, рвота, гипокоагуляция, кровотечения; снижение остроты слуха, бронхоспазм.

Передозировка

Симптомы: звон в ушах, головокружение, головная боль, гастралгия,тошнота, рвота, гипервентиляция легких центрального генеза, респираторный алкалоз, метаболический ацидоз, заторможенность, сонливость, коллапс, судороги, затрудненное дыхание, анурия, кровотечения.Лечение: постоянный контроль за КОС и электролитным балансом; в зависимости от состояния обмена веществ — введение натрия гидрокарбоната, натрия цитрата или натрия лактата. Повышение резервной щелочности усиливает выведение АСК за счет ощелачивания мочи.

Взаимодействие Дисприн таблетки 500мг

Усиливает действие гепарина, пероральных антикоагулянтов и гипогликемических ЛС, резерпина, стероидных гормонов. НПВП и метотрексат увеличивают риск развития побочных эффектов. Q-T.

Особые указания

Детям нельзя назначать ЛС, содержащие ацетилсалисиловую кислоту. При продолжительном применении препарата необходим контроль периферической крови и функционального состояния печени. Во время лечения следует отказаться от употребления этанола. Ацетилсалициловая кислота выделяется с грудным молоком, что повышает риск возникновения кровотечений у ребенка вследствие нарушения функции тромбоцитов.

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Фармакологическое действие
Комбинированный препарат, действие которого обусловлено входящими в его состав компонентами; оказывает противовоспалительное, жаропонижающее, антиагрегантное, анальгезирующее действие. 

Показания к применению
Ревматизм, ревматоидный артрит, инфекционно-аллергический миокардит; лихорадочный синдром при инфекционно-воспалительных заболеваниях, болевой синдром, головная боль, мигрень, зубная боль, невралгия, миалгия, артралгия, альгодисменорея, тромбоз и тромбоэмболия (профилактика), инфаркт миокарда (вторичная профилактика), транзиторные ишемические нарушения мозгового кровообращения.

Противопоказания
Гиперчувствительность к салицилатам и др. НПВП, язвенная болезнь желудка и 12-перстной кишки (в стадии обострения), желудочно-кишечное кровотечение, «аспириновая» астма, гемофилия, геморрагический диатез, гипопротромбинемия, портальная гипертензия, авитаминоз K, тяжелая почечная и/или печеночная недостаточность, беременность (I и III триместры), период лактации, дефицит глюкозо-6-фосфатдегидрогеназы, повышенная склонность к кровотечениям, детский возраст до 15 лет . C осторожностью: подагра, заболевания печени, одновременное применение др. НПВП или урикозурических ЛС, антикоагулянтов непрямого действия, тиклопидина, гепарина, интерферона альфа, метотрексата.

Побочное действие
Тошнота, снижение аппетита, гастралгия, диарея, эрозивно-язвенные поражения ЖКТ, кровотечения в ЖКТ, аллергические реакции, печеночная и/или почечная недостаточность, тромбоцитопения, анемия, лейкопения. При длительном применении — головокружение, головная боль, нарушения зрения, шум в ушах, рвота, гипокоагуляция, кровотечения; снижение остроты слуха, бронхоспазм.

Взаимодействие
Усиливает действие гепарина, пероральных антикоагулянтов и гипогликемических ЛС, резерпина, стероидных гормонов. НПВП и метотрексат увеличивают риск развития побочных эффектов. Q-T.

Передозировка
Симптомы: звон в ушах, головокружение, головная боль, гастралгия,тошнота, рвота, гипервентиляция легких центрального генеза, респираторный алкалоз, метаболический ацидоз, заторможенность, сонливость, коллапс, судороги, затрудненное дыхание, анурия, кровотечения. Лечение: постоянный контроль за КОС и электролитным балансом; в зависимости от состояния обмена веществ — введение натрия гидрокарбоната, натрия цитрата или натрия лактата. Повышение резервной щелочности усиливает выведение АСК за счет ощелачивания мочи.

Способ применения и дозировка
Внутрь. Взрослым — в разовой дозе 1-2 таблетки; максимальная суточная доза — 8 таблеток.
Детям — разовая доза 0.5-1.5 таблетки; максимальная суточная доза — 4 таблетки.

Особые указания
Детям нельзя назначать ЛС, содержащие ацетилсалисиловую кислоту. При продолжительном применении препарата необходим контроль периферической крови и функционального состояния печени. Во время лечения следует отказаться от употребления этанола. Ацетилсалициловая кислота выделяется с грудным молоком, что повышает риск возникновения кровотечений у ребенка вследствие нарушения функции тромбоцитов.

Условия хранения
Хранить в сухом, защищенном от света месте.

Медицинская энциклопедия
Медицинский справочник
Главная >> Лекарства >> Лекарственные средства на букву Д


Дисприн

Лекарственные формы
таблетки 500мг

Производители
Рекитт и Колман(Индия)

ФармГруппа
Противовоспалительные средства — производные салициловой кислоты

Международное непатентованное наименование
Ацетилсалициловая кислота+Лимонная кислота+Кальция карбонат

Синонимы
Инсприн

Состав
Ацетилсалициловая кислота+Лимонная кислота+Кальция карбонат.

Фармакологическое действие
Комбинированный препарат, действие которого обусловлено входящими в его состав компонентами; оказывает противовоспалительное, жаропонижающее, антиагрегантное, анальгезирующее действие.

Показания к применению
Ревматизм, ревматоидный артрит, инфекционно-аллергический миокардит; лихорадочный синдром при инфекционно-воспалительных заболеваниях, болевой синдром, головная боль, мигрень, зубная боль, невралгия, миалгия, артралгия, альгодисменорея, тромбоз и тромбоэмболия (профилактика), инфаркт миокарда (вторичная профилактика), транзиторные ишемические нарушения мозгового кровообращения.

Противопоказания
Гиперчувствительность к салицилатам и др. НПВП, язвенная болезнь желудка и 12-перстной кишки (в стадии обострения), желудочно-кишечное кровотечение, «аспириновая» астма, гемофилия, геморрагический диатез, гипопротромбинемия, портальная гипертензия, авитаминоз K, тяжелая почечная и/или печеночная недостаточность, беременность (I и III триместры), период лактации, дефицит глюкозо-6-фосфатдегидрогеназы, повышенная склонность к кровотечениям, детский возраст до 15 лет .C осторожностью: подагра, заболевания печени, одновременное применение др. НПВП или урикозурических ЛС, антикоагулянтов непрямого действия, тиклопидина, гепарина, интерферона альфа, метотрексата.

Побочное действие
Тошнота, снижение аппетита, гастралгия, диарея, эрозивно-язвенные поражения ЖКТ, кровотечения в ЖКТ, аллергические реакции, печеночная и/или почечная недостаточность, тромбоцитопения, анемия, лейкопения. При длительном применении — головокружение, головная боль, нарушения зрения, шум в ушах, рвота, гипокоагуляция, кровотечения; снижение остроты слуха, бронхоспазм.

Взаимодействие
Усиливает действие гепарина, пероральных антикоагулянтов и гипогликемических ЛС, резерпина, стероидных гормонов. НПВП и метотрексат увеличивают риск развития побочных эффектов. Q-T.

Передозировка
Симптомы: звон в ушах, головокружение, головная боль, гастралгия,тошнота, рвота, гипервентиляция легких центрального генеза, респираторный алкалоз, метаболический ацидоз, заторможенность, сонливость, коллапс, судороги, затрудненное дыхание, анурия, кровотечения.Лечение: постоянный контроль за КОС и электролитным балансом; в зависимости от состояния обмена веществ — введение натрия гидрокарбоната, натрия цитрата или натрия лактата. Повышение резервной щелочности усиливает выведение АСК за счет ощелачивания мочи.

Особые указания
Детям нельзя назначать ЛС, содержащие ацетилсалисиловую кислоту. При продолжительном применении препарата необходим контроль периферической крови и функционального состояния печени. Во время лечения следует отказаться от употребления этанола. Ацетилсалициловая кислота выделяется с грудным молоком, что повышает риск возникновения кровотечений у ребенка вследствие нарушения функции тромбоцитов.

Литература
Типовая клинико-фармакологическая статья.


Смотрите также:
Дексаметазон фосфат,   Доктор Тайсс Леденцы с вкусом липы и лимона + витамин С,   Дофамин-Ферейн,   Дилтизем СР,   Дезоксинат


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Дисприн

Active substance(s): ASPIRIN

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SUMMARY OF PRODUCT CHARACTERISTICS

1

NAME OF THE MEDICINAL PRODUCT
Disprin

2

3

QUALITATIVE AND QUANTITATIVE COMPOSITION
Active Ingredient

mg/Tablet

Specification

Aspirin

300.00

Ph Eur

PHARMACEUTICAL FORM
Dispersible tablet

4

CLINICAL PARTICULARS

4.1

Therapeutic indications
For the relief of mild to moderate pain in headaches, including migraine headaches,
toothache, neuralgia, sciatica, period pains and sore throats.
Reduction of temperature in feverishness, influenza and colds.
Reduction of inflammation in rheumatism and lumbago.

4.2

Posology and method of administration
Oral administration after dissolution in water.
Adults (including children 16 years and over): Two to three tablets every 4 hours. Do
not exceed 13 tablets in 24 hours.
Do not give to children aged under 16 years unless specifically indicated (e.g. for
Kawasaki’s disease).

There is no indication that dosage need be modified in the elderly.

4.3

Contraindications
Should not be given to patients suffering from a previous history of peptic ulceration
or active peptic ulceration or haemophilia.

4.4

Special warnings and precautions for use
The product labelling will include:
Do not give to children under 16 years unless on the advice of a doctor.
Keep out of reach of children.
If you are receiving regular medical treatment, are asthmatic, allergic to aspirin or
have or have had a stomach ulcer, seek your doctor’s advice before taking this
product.
There is a possible association between aspirin and Reye’s Syndrome when given to
children. Reye’s Syndrome is a very rare disease which affects the brain and liver and
can be fatal. For this reason aspirin should not be given to children aged under 16
years unless specifically indicated (e.g. for Kawasaki’s disease).

4.5

Interaction with other medicinal products and other forms of interaction
Aspirin may enhance the effects of anticoagulants and inhibit the effects of
uricosurics.
Experimental data suggest that ibuprofen may inhibit the effect of low dose
aspirin on platelet aggregation when they are dosed concomitantly. However,
the limitations of these data and the uncertainties regarding extrapolation of
ex-vivo data to the clinical situation imply that no firm conclusions can be
made for regular ibuprofen use, and no clinically relevant effect is considered
to be likely for occasional ibuprofen use (see section 5.1).

4.6

Pregnancy and lactation
There is clinical and epidemiological evidence of the safety of aspirin in human
pregnancy, but it may prolong labour and contribute to maternal and neonatal
bleeding and is best avoided at term and during breastfeeding.

4.7

Effects on ability to drive and use machines
None known.

4.8

Undesirable effects
May precipitate bronchospasm and induce attacks of asthma or hypersensitivity in
susceptible subjects. May also induce gastrointestinal haemorrhage, occasionally
major.

4.9

Overdose
Salicylate poisoning is usually associated with plasma concentrations >350 mg/L (2.5
mmol/L). Most adult deaths occur in patients whose concentrations exceed 700 mg/L
(5.1 mmol/L). Single doses less than 100 mg/kg are unlikely to cause serious
poisoning.
Symptoms
Common features include vomiting, dehydration, tinnitus, vertigo, deafness,
sweating, warm extremities with bounding pulses, increased respiratory rate and
hyperventilation. Some degree of acid-base disturbance is present in most cases.
A mixed respiratory alkalosis and metabolic acidosis with normal or high arterial pH
(normal or reduced hydrogen ion concentration) is usual in adults and children over
the age of four years. In children aged four years or less, a dominant metabolic
acidosis with low arterial pH (raised hydrogen ion concentration) is common.
Acidosis may increase salicylate transfer across the blood brain barrier.
Uncommon features include haematemesis, hyperpyrexia, hypoglycaemia,
hypokalaemia, thrombocytopaenia, increased INR/PTR, intravascular coagulation,
renal failure and non-cardiac pulmonary oedema.
Central nervous system features including confusion, disorientation, coma and
convulsions are less common in adults than in children.
Management
Give activated charcoal if an adult presents within one hour of ingestion of more than
250 mg/kg. The plasma salicylate concentration should be measured, although the
severity of poisoning cannot be determined from this alone and the clinical and

biochemical features must be taken into account. Elimination is increased by urinary
alkalinisation, which is achieved by the administration of 1.26% sodium bicarbonate.
The urine pH should be monitored. Correct metabolic acidosis with intravenous 8.4%
sodium bicarbonate (first check serum potassium). Forced diuresis should not be used
since it does not enhance salicylate excretion and may cause pulmonary oedema.
Haemodialysis is the treatment of choice for severe poisoning and should be
considered in patients with plasma salicylate concentrations >700 mg/L (5.1
mmol/L), or lower concentrations associated with severe clinical or metabolic
features. Patients under ten years or over 70 have increased risk of salicylate toxicity
and may require dialysis at an earlier stage.

5

PHARMACOLOGICAL PROPERTIES

5.1

Pharmacodynamic properties
Aspirin:
Aspirin inhibits the cyclo-oxygenase enzyme involved in conversion of phospholipids
to prostaglandins and its effects on the body are believed to result primarily from
prevention of prostaglandin production. These effects include peripheral analgesia,
fever reduction, reduction in inflammation and inhibition of platelet aggregation.
Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on
platelet aggregation when they are dosed concomitantly. In one study, when a single
dose of ibuprofen 400mg was taken within 8 hours before or within 30 minutes after
immediate release aspirin dosing (81mg), a decreased effect of aspirin on the
formation of thromboxane or platelet aggregation occurred. However, the limitations
of these data and the uncertainties regarding extrapolation of ex vivo data to the
clinical situation imply that no firm conclusions can be made for regular ibuprofen
use, and no clinically relevant effect is considered to be like for occasional ibuprofen
use.

5.2

Pharmacokinetic properties
Aspirin is rapidly absorbed from the stomach and upper gastrointestinal tract with
peak levels after around 20-30 minutes following dissolution. It is subject to first-pass
metabolism with an overall bioavailability of around 70%. Metabolism is by
conversion to salicylic acid and then by further conversion to other metabolites.
These are excreted by the kidneys in both free and conjugated form. The plasma halflife of aspirin is around 15-20 minutes and that of salicylic acid is 2-3 hours.

5.3

Preclinical safety data
No preclinical findings of relevance have been reported.

6

PHARMACEUTICAL PARTICULARS

6.1

List of excipients
Calcium carbonate, maize starch, citric acid, talc, sodium lauryl sulphate, saccharin,
crospovidone and lime flavour.

6.2

Incompatibilities
None known.

6.3

Shelf life
Three years.

6.4

Special precautions for storage
Store below 25°C in a dry place.

6.5

Nature and contents of container
Cardboard carton containing tablets in strips of aluminium foil with vinyl heat seal.
Pack sizes: 6, 8, 12, 16, 24, 32, 48, 96 and 500 tablets. (Those pack sizes printed in
bold are currently sold).

6.6

Special precautions for disposal
Oral administration after dissolution in water.

7

MARKETING AUTHORISATION HOLDER
Reckitt Benekiser Healthcare (UK) Limited
Dansom Lane
Hull
HU8 7DS
United Kingdom.

8

MARKETING AUTHORISATION NUMBER(S)
PL 00063/0017.

9

DATE OF FIRST AUTHORISATION/RENEWAL OF THE
AUTHORISATION
24/04/1995 / 23/02/2004

10

DATE OF REVISION OF THE TEXT
26/01/2009

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Suffering from headaches, your mother might have recommended disprin. 

Disprin is a commonly used pain killer which contains Aspirin. It is often recommended if one is suffering from muscle or joint pain, toothache as well as menstrual pain. Several general physicians might also prescribe this medication for fever, sore throat, cold, and cough. 

Aspirin which is a common component of disprin is an anti-inflammatory compound that reduces inflammation and thus helps with pain. Always remember to take disprin after consulting with a doctor. 

Let us educate more on the various aspects of disprin tablet uses. Make sure to pay attention. 

How does Disprin Tablet Works?

Disprin tablets act on the body by blocking the action of certain enzymes and chemicals. This tablet interferes with the release of these enzymes as well as reduces inflammation, pain, and fever. 

It is one of the most commonly recommended painkillers for pain and fever and is one of the best remedies to treat headaches because of the symptomatic relief that it causes. 

How to take Disprin Tablets?

Make sure to consult with your doctor before taking any sort of medication. You should not crush or chew it. Try to swallow it as a whole. Refrain from taking medicines without any sort of prescription or doctor’s consultation. 

What are Disprin Tablet Uses?

Your doctor can prescribe you disprin if you have the following conditions:

1. Pain and fever 

The Disprin tablet is used to reduce fever and relieve pain in muscles and the body. 

2. Rheumatic Fever

Disprin Tablet is used to reduce the overall instances of inflammation during rheumatic fever. 

3. Acute Coronary Syndrome

An acute coronary syndrome is a condition in which a person suffers from blocked flow to the cardiac muscle. A Disprin tablet is then used to treat this condition. 

4. Kawasaki Disease

Kawasaki disease is a medical condition in which a person suffers from inflammation of the blood vessels. Doctors often prescribe aspirin for the treatment of Kawasaki disease. 

5. Arthritis

Disprin is often recommended to treat the inflammation, swelling, pain, and stiffness due to arthritis. Your doctor might recommend an anti-ccp test for an arthritis diagnosis. 

What are Disprin Side Effects?

Disprin uses also come with its fair share of side effects. Some common disprin side effects are as follows:

  • Nasal bleeding
  • Dizziness
  • Hearing issues
  • Confusion
  • Stomachache
  • Nausea
  • Vomiting
  • Increased bleeding can lead to severe bleeding instances even after minor cuts

You need to stop taking disprin or should contact your doctor if you experience the following:

  • Allergic reactions – as in skin rashes, swelling of lips, body, and face. Rash that leads to worsening of asthma and difficulty in swelling
  • Bleeding in the stomach – coughing up blood, vomiting in blood, urine, and feces, black stools, severe stomach pain, loss of appetite, heartburn, bleeding in the brain, and severe headache

What is the Disprin Tablet Formula?

Active Ingredient mg/Tablet Specification
Aspirin 300.00 Ph Eur

How to Manage Disprin Side Effects?

It is quite possible to manage the side effects of disprin tablets. Given below are some effective ways to manage disprin side effects:

1. In Case of Nausea and Vomiting

If you are experiencing nausea and vomiting after a dose of nausea and vomiting then you should consult with your doctor. You should take disprin after a meal. Moreover, try to avoid spicy and oily foods so that your stomach may not have to bear the consequences. 

2. In Case of Dizziness

If you are feeling dizzy then you should try to rest and relax. Make sure to avoid those tasks that demand concentration and focus such as driving. If the symptoms are not improving, consult a doctor right away!

3. In Case of Stomachache

Try to consume foods in small bites so that your stomach does not have to work hard to digest them. Keep a track of your fluids intakes such as juices or water. It will ease the heartburn and you will get rid of the excruciating stomach pain.

What are the Precautions of Disprin Tablet Uses?

Given below are some warnings related to disprin tablet uses that you need to keep in mind. 

1. During Pregnancy

Doctors do not recommend disprin to pregnant women, especially during the last trimesters of pregnancy. 

2. During Breastfeeding

Unless and until prescribed by your doctor, you should refrain from disprin tablets. 

3. During Driving

You should not take disprin if you are entitled to motor works such as driving and use of the machine. Disprin tablet uses can induce dizziness and thus refrain from taking disprin during such tasks. 

4. Suffering from Kidney Issues

If you have a medical history of kidney diseases then you should not take disprin without a doctor’s consultation. 

5. Suffering from Liver Diseases

Those who are suffering from liver conditions are recommended to stay away from disprin. They should only take those medications which are prescribed by their general physicians. 

6. Suffering from Cardiac Issues

If you are suffering from serious heart health issues, then you should refrain from using disprin tablets. It can lead to high blood pressure and subsequent health complications. 

A Note from Healthwire

Disprin tablet is widely known for its pain-relieving impacts on the body. This is an oral medication but it is not prescribed to children below 16. Generally a safe medicine you should never take without consultation.

 Refrain from relying on your gut and self-medication tactics. You should always consult with a doctor before taking any sort of medication for pain and fever.

Healthwire offers some of the best general physicians across the country who are available for virtual and in-person consultations.  

Commonly Asked Questions

How long do the effects of disprin last?

The effects of disprin may last for an average of 4 to 6 hours

Is it okay to take disprin during pregnancy or breastfeeding?

No, doctors do not recommend disprin for pregnant and breastfeeding women. 

How long does it take for Disprin to take effect in the body?

After an oral dose, the effects of the disprin tablet can be observed in 5 to 30 minutes. 

Can I take disprin and paracetamol together?

No, you should not take disprin with any other NSAID such as paracetamol. It can lead to potential side effects. If you take it then you should consult a doctor right away.

Can I give disprin to my child?

Doctors do not often recommend disprin tablets to children. It is mostly because of certain side effects that this drug can lead to. 

Medical Portal © 2007-2017

Дисприн

Active substance(s): ASPIRIN

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PDF Transcript

SUMMARY OF PRODUCT CHARACTERISTICS

1

NAME OF THE MEDICINAL PRODUCT
Disprin

2

3

QUALITATIVE AND QUANTITATIVE COMPOSITION
Active Ingredient

mg/Tablet

Specification

Aspirin

300.00

Ph Eur

PHARMACEUTICAL FORM
Dispersible tablet

4

CLINICAL PARTICULARS

4.1

Therapeutic indications
For the relief of mild to moderate pain in headaches, including migraine headaches,
toothache, neuralgia, sciatica, period pains and sore throats.
Reduction of temperature in feverishness, influenza and colds.
Reduction of inflammation in rheumatism and lumbago.

4.2

Posology and method of administration
Oral administration after dissolution in water.
Adults (including children 16 years and over): Two to three tablets every 4 hours. Do
not exceed 13 tablets in 24 hours.
Do not give to children aged under 16 years unless specifically indicated (e.g. for
Kawasaki’s disease).

There is no indication that dosage need be modified in the elderly.

4.3

Contraindications
Should not be given to patients suffering from a previous history of peptic ulceration
or active peptic ulceration or haemophilia.

4.4

Special warnings and precautions for use
The product labelling will include:
Do not give to children under 16 years unless on the advice of a doctor.
Keep out of reach of children.
If you are receiving regular medical treatment, are asthmatic, allergic to aspirin or
have or have had a stomach ulcer, seek your doctor’s advice before taking this
product.
There is a possible association between aspirin and Reye’s Syndrome when given to
children. Reye’s Syndrome is a very rare disease which affects the brain and liver and
can be fatal. For this reason aspirin should not be given to children aged under 16
years unless specifically indicated (e.g. for Kawasaki’s disease).

4.5

Interaction with other medicinal products and other forms of interaction
Aspirin may enhance the effects of anticoagulants and inhibit the effects of
uricosurics.
Experimental data suggest that ibuprofen may inhibit the effect of low dose
aspirin on platelet aggregation when they are dosed concomitantly. However,
the limitations of these data and the uncertainties regarding extrapolation of
ex-vivo data to the clinical situation imply that no firm conclusions can be
made for regular ibuprofen use, and no clinically relevant effect is considered
to be likely for occasional ibuprofen use (see section 5.1).

4.6

Pregnancy and lactation
There is clinical and epidemiological evidence of the safety of aspirin in human
pregnancy, but it may prolong labour and contribute to maternal and neonatal
bleeding and is best avoided at term and during breastfeeding.

4.7

Effects on ability to drive and use machines
None known.

4.8

Undesirable effects
May precipitate bronchospasm and induce attacks of asthma or hypersensitivity in
susceptible subjects. May also induce gastrointestinal haemorrhage, occasionally
major.

4.9

Overdose
Salicylate poisoning is usually associated with plasma concentrations >350 mg/L (2.5
mmol/L). Most adult deaths occur in patients whose concentrations exceed 700 mg/L
(5.1 mmol/L). Single doses less than 100 mg/kg are unlikely to cause serious
poisoning.
Symptoms
Common features include vomiting, dehydration, tinnitus, vertigo, deafness,
sweating, warm extremities with bounding pulses, increased respiratory rate and
hyperventilation. Some degree of acid-base disturbance is present in most cases.
A mixed respiratory alkalosis and metabolic acidosis with normal or high arterial pH
(normal or reduced hydrogen ion concentration) is usual in adults and children over
the age of four years. In children aged four years or less, a dominant metabolic
acidosis with low arterial pH (raised hydrogen ion concentration) is common.
Acidosis may increase salicylate transfer across the blood brain barrier.
Uncommon features include haematemesis, hyperpyrexia, hypoglycaemia,
hypokalaemia, thrombocytopaenia, increased INR/PTR, intravascular coagulation,
renal failure and non-cardiac pulmonary oedema.
Central nervous system features including confusion, disorientation, coma and
convulsions are less common in adults than in children.
Management
Give activated charcoal if an adult presents within one hour of ingestion of more than
250 mg/kg. The plasma salicylate concentration should be measured, although the
severity of poisoning cannot be determined from this alone and the clinical and

biochemical features must be taken into account. Elimination is increased by urinary
alkalinisation, which is achieved by the administration of 1.26% sodium bicarbonate.
The urine pH should be monitored. Correct metabolic acidosis with intravenous 8.4%
sodium bicarbonate (first check serum potassium). Forced diuresis should not be used
since it does not enhance salicylate excretion and may cause pulmonary oedema.
Haemodialysis is the treatment of choice for severe poisoning and should be
considered in patients with plasma salicylate concentrations >700 mg/L (5.1
mmol/L), or lower concentrations associated with severe clinical or metabolic
features. Patients under ten years or over 70 have increased risk of salicylate toxicity
and may require dialysis at an earlier stage.

5

PHARMACOLOGICAL PROPERTIES

5.1

Pharmacodynamic properties
Aspirin:
Aspirin inhibits the cyclo-oxygenase enzyme involved in conversion of phospholipids
to prostaglandins and its effects on the body are believed to result primarily from
prevention of prostaglandin production. These effects include peripheral analgesia,
fever reduction, reduction in inflammation and inhibition of platelet aggregation.
Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on
platelet aggregation when they are dosed concomitantly. In one study, when a single
dose of ibuprofen 400mg was taken within 8 hours before or within 30 minutes after
immediate release aspirin dosing (81mg), a decreased effect of aspirin on the
formation of thromboxane or platelet aggregation occurred. However, the limitations
of these data and the uncertainties regarding extrapolation of ex vivo data to the
clinical situation imply that no firm conclusions can be made for regular ibuprofen
use, and no clinically relevant effect is considered to be like for occasional ibuprofen
use.

5.2

Pharmacokinetic properties
Aspirin is rapidly absorbed from the stomach and upper gastrointestinal tract with
peak levels after around 20-30 minutes following dissolution. It is subject to first-pass
metabolism with an overall bioavailability of around 70%. Metabolism is by
conversion to salicylic acid and then by further conversion to other metabolites.
These are excreted by the kidneys in both free and conjugated form. The plasma halflife of aspirin is around 15-20 minutes and that of salicylic acid is 2-3 hours.

5.3

Preclinical safety data
No preclinical findings of relevance have been reported.

6

PHARMACEUTICAL PARTICULARS

6.1

List of excipients
Calcium carbonate, maize starch, citric acid, talc, sodium lauryl sulphate, saccharin,
crospovidone and lime flavour.

6.2

Incompatibilities
None known.

6.3

Shelf life
Three years.

6.4

Special precautions for storage
Store below 25°C in a dry place.

6.5

Nature and contents of container
Cardboard carton containing tablets in strips of aluminium foil with vinyl heat seal.
Pack sizes: 6, 8, 12, 16, 24, 32, 48, 96 and 500 tablets. (Those pack sizes printed in
bold are currently sold).

6.6

Special precautions for disposal
Oral administration after dissolution in water.

7

MARKETING AUTHORISATION HOLDER
Reckitt Benekiser Healthcare (UK) Limited
Dansom Lane
Hull
HU8 7DS
United Kingdom.

8

MARKETING AUTHORISATION NUMBER(S)
PL 00063/0017.

9

DATE OF FIRST AUTHORISATION/RENEWAL OF THE
AUTHORISATION
24/04/1995 / 23/02/2004

10

DATE OF REVISION OF THE TEXT
26/01/2009

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Suffering from headaches, your mother might have recommended disprin. 

Disprin is a commonly used pain killer which contains Aspirin. It is often recommended if one is suffering from muscle or joint pain, toothache as well as menstrual pain. Several general physicians might also prescribe this medication for fever, sore throat, cold, and cough. 

Aspirin which is a common component of disprin is an anti-inflammatory compound that reduces inflammation and thus helps with pain. Always remember to take disprin after consulting with a doctor. 

Let us educate more on the various aspects of disprin tablet uses. Make sure to pay attention. 

How does Disprin Tablet Works?

Disprin tablets act on the body by blocking the action of certain enzymes and chemicals. This tablet interferes with the release of these enzymes as well as reduces inflammation, pain, and fever. 

It is one of the most commonly recommended painkillers for pain and fever and is one of the best remedies to treat headaches because of the symptomatic relief that it causes. 

How to take Disprin Tablets?

Make sure to consult with your doctor before taking any sort of medication. You should not crush or chew it. Try to swallow it as a whole. Refrain from taking medicines without any sort of prescription or doctor’s consultation. 

What are Disprin Tablet Uses?

Your doctor can prescribe you disprin if you have the following conditions:

1. Pain and fever 

The Disprin tablet is used to reduce fever and relieve pain in muscles and the body. 

2. Rheumatic Fever

Disprin Tablet is used to reduce the overall instances of inflammation during rheumatic fever. 

3. Acute Coronary Syndrome

An acute coronary syndrome is a condition in which a person suffers from blocked flow to the cardiac muscle. A Disprin tablet is then used to treat this condition. 

4. Kawasaki Disease

Kawasaki disease is a medical condition in which a person suffers from inflammation of the blood vessels. Doctors often prescribe aspirin for the treatment of Kawasaki disease. 

5. Arthritis

Disprin is often recommended to treat the inflammation, swelling, pain, and stiffness due to arthritis. Your doctor might recommend an anti-ccp test for an arthritis diagnosis. 

What are Disprin Side Effects?

Disprin uses also come with its fair share of side effects. Some common disprin side effects are as follows:

  • Nasal bleeding
  • Dizziness
  • Hearing issues
  • Confusion
  • Stomachache
  • Nausea
  • Vomiting
  • Increased bleeding can lead to severe bleeding instances even after minor cuts

You need to stop taking disprin or should contact your doctor if you experience the following:

  • Allergic reactions – as in skin rashes, swelling of lips, body, and face. Rash that leads to worsening of asthma and difficulty in swelling
  • Bleeding in the stomach – coughing up blood, vomiting in blood, urine, and feces, black stools, severe stomach pain, loss of appetite, heartburn, bleeding in the brain, and severe headache

What is the Disprin Tablet Formula?

Active Ingredient mg/Tablet Specification
Aspirin 300.00 Ph Eur

How to Manage Disprin Side Effects?

It is quite possible to manage the side effects of disprin tablets. Given below are some effective ways to manage disprin side effects:

1. In Case of Nausea and Vomiting

If you are experiencing nausea and vomiting after a dose of nausea and vomiting then you should consult with your doctor. You should take disprin after a meal. Moreover, try to avoid spicy and oily foods so that your stomach may not have to bear the consequences. 

2. In Case of Dizziness

If you are feeling dizzy then you should try to rest and relax. Make sure to avoid those tasks that demand concentration and focus such as driving. If the symptoms are not improving, consult a doctor right away!

3. In Case of Stomachache

Try to consume foods in small bites so that your stomach does not have to work hard to digest them. Keep a track of your fluids intakes such as juices or water. It will ease the heartburn and you will get rid of the excruciating stomach pain.

What are the Precautions of Disprin Tablet Uses?

Given below are some warnings related to disprin tablet uses that you need to keep in mind. 

1. During Pregnancy

Doctors do not recommend disprin to pregnant women, especially during the last trimesters of pregnancy. 

2. During Breastfeeding

Unless and until prescribed by your doctor, you should refrain from disprin tablets. 

3. During Driving

You should not take disprin if you are entitled to motor works such as driving and use of the machine. Disprin tablet uses can induce dizziness and thus refrain from taking disprin during such tasks. 

4. Suffering from Kidney Issues

If you have a medical history of kidney diseases then you should not take disprin without a doctor’s consultation. 

5. Suffering from Liver Diseases

Those who are suffering from liver conditions are recommended to stay away from disprin. They should only take those medications which are prescribed by their general physicians. 

6. Suffering from Cardiac Issues

If you are suffering from serious heart health issues, then you should refrain from using disprin tablets. It can lead to high blood pressure and subsequent health complications. 

A Note from Healthwire

Disprin tablet is widely known for its pain-relieving impacts on the body. This is an oral medication but it is not prescribed to children below 16. Generally a safe medicine you should never take without consultation.

 Refrain from relying on your gut and self-medication tactics. You should always consult with a doctor before taking any sort of medication for pain and fever.

Healthwire offers some of the best general physicians across the country who are available for virtual and in-person consultations.  

Commonly Asked Questions

How long do the effects of disprin last?

The effects of disprin may last for an average of 4 to 6 hours

Is it okay to take disprin during pregnancy or breastfeeding?

No, doctors do not recommend disprin for pregnant and breastfeeding women. 

How long does it take for Disprin to take effect in the body?

After an oral dose, the effects of the disprin tablet can be observed in 5 to 30 minutes. 

Can I take disprin and paracetamol together?

No, you should not take disprin with any other NSAID such as paracetamol. It can lead to potential side effects. If you take it then you should consult a doctor right away.

Can I give disprin to my child?

Doctors do not often recommend disprin tablets to children. It is mostly because of certain side effects that this drug can lead to. 

Naba Batool

Naba Batool is an environmental researcher who loves to converse with the audience through her writings. She is currently associated with Healthwire.pk as a content writer and a science journalist.

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