Колдфри®
МНН: Кофеин, Парацетамол, Фенилэфрин, Хлорфенирамина малеат (Хлорфенамин)
Производитель: Медлей Фармасьютикалз Лимитед
Анатомо-терапевтическо-химическая классификация: Парацетамол в комбинации с другими препаратами (исключая психолептики)
Номер регистрации в РК:
№ РК-ЛС-5№019921
Информация о регистрации в РК:
12.11.2018 — 12.11.2023
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Торговое название
Колдфри®
Международное непатентованное название
Нет
Лекарственная форма
Таблетки
Состав
Одна дневная таблетка содержит
активные вещества: парацетамола 500.0 мг
хлорфенирамина малеата 2.0 мг
фенилэфрина гидрохлорида 5.0 мг
кофеина (безводного) 15.0 мг
вспомогательные вещества: крахмал кукурузный, повидон К-30, желатин, магния стеарат, хинолиновый желтый Е104, железа оксид желтый Е172, бриллиантовый синий Е133, метилпарабен, пропилпарабен.
Одна ночная таблетка содержит
активные вещества: парацетамола 500.0 мг
хлорфенирамина малеата 4.0 мг
фенилэфрина гидрохлорида 10.0 мг
вспомогательные вещества: крахмал кукурузный, повидон К-30, желатин, магния стеарат, хинолиновый желтый Е104, железа оксид желтый Е172, бриллиантовый синий Е133, метилпарабен, пропилпарабен.
Описание
Таблетки круглой формы с плоской поверхностью светло-желтого (дневные) и светло-зеленого (ночные) цвета, с риской на одной стороне и гравировкой «Medley» на другой стороне.
Фармакотерапевтическая группа
Анальгетики-антипиретики другие. Анилиды. Парацетамол в комбинации
с другими препаратами.
Код АТХ N02BE51
Фармакологические свойства
Фармакокинетика
После приема внутрь парацетамол быстро абсорбируется из желудочно-кишечного тракта (ЖКТ), преимущественно в тонком кишечнике. После однократного приема в дозе 500 мг максимальная концентрация в плазме крови (Сmax) достигается через 10-60 мин и составляет около 6 мкг/мл, затем постепенно снижается и через 6 ч составляет 11-12 мкг/мл. Связывание с белками крови составляет менее 10%. Выводится с мочой главным образом в виде глюкуронидных и сульфатных конъюгатов.
Кофеин метаболизируется в печени (97%) в 1- 7-метилксантин, 1,7-диметилметилксантин и 1,3-диметилмочевой кислоты, которые выводятся с мочой.
После приема внутрь фенилэфрин плохо всасывается из ЖКТ. Метаболизируется при участии МАО в стенке кишечника и при «первом прохождении» через печень. Биодоступность фенилэфрина низкая.
Хлорфенирамин хорошо проникает в разные ткани и через гематоэнцефалический барьер. Метаболизируется в печени путем метилирования. Выводится в виде метаболитов и в неизмененном виде почками и желудочно-кишечным трактом (ЖКТ).
Фармакодинамика
Колдфри® комбинированный препарат обладает анальгезирующим, жаропонижающим и противоаллергическим действиями, обусловленными активными веществами, входящими в состав препарата.
Парацетамол – нестероидное противовоспалительное средство, оказывает жаропонижающее, анальгетическое и противовоспалительное действие.
Хлорфенирамина малеат – антигистаминное средство, антагонист Н1-гистаминовых рецепторов, оказывает противоотечное действие.
Фенилэфрина гидрохлорид – селективный агонист ά1-адренорецепторов, оказывает сосудосуживающее действие, способствуя тем самым устранению заложенности носа и уменьшению выделений из носа.
Кофеина ангидрид – психостимулирующее средство, производное пурина, повышает умственную и физическую работоспособность, снижая усталость и сонливость. Уменьшает сонливость, вызванную хлорфенирамином.
Показания к применению
Для устранения заложенности носа, выделений из носа, чихания, головной боли, болей в теле и конечностях, высокой температуры при:
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простудных заболеваниях
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гриппе
-
остром рините, синусите
Способ применения и дозы
Взрослым: 1 светло-желтая таблетка (Колдфри® дневные таблетки) – утром и днем, 1 светло-зеленая таблетка (Колдфри® ночные таблетки) – на ночь.
Таблетки принимают в течении 3-х дней, запивая водой, фруктовым соком или молоком. Не рекомендуется превышать указанные дозы и принимать Колдфри® ночные таблетки в течение дня.
Побочные действия
— кожная сыпь, зуд, крапивница, ангионевротический отек
— головокружение, нарушение засыпания, повышенная возбудимость
— повышение артериального давления, тахикардия
— тошнота, рвота, эпигастральная боль, сухость во рту
— задержка мочи
— парез аккомодации, повышение внутриглазного давления, мидриаз
— анемия, тромбоцитопения, агранулоцитоз, гемолитическая анемия, апластическая анемия, метгемоглобинемия, панцитопения
— гепатотоксическое действие
— нефротоксичность (папиллярный некроз)
— бронхообструкция.
— при длительном применении, особенно в больших дозах, возможно развитие метгемоглобинемии, анемии, нефротоксического и гепатотоксического действия.
С осторожностью – выраженный атеросклероз коронарных артерий, артериальная гипертензия, тиреотоксикоз, феохромоцитома, сахарный диабет, бронхиальная астма, хроническая обструктивная болезнь легких, дефицит глюкозо-6-фосфатдегидрогеназы, заболевания крови, врожденные гипербилирубинемии (синдромы Жильбера, Дубина-Джонсона и Ротора), печеночная и/или почечная недостаточность, закрытоугольная глаукома, гиперплазия предстательной железы.
Противопоказания
— повышенная чувствительность к компонентам препарата
— одновременный прием трициклических антидепрессантов, ингибиторов МАО, бета-адреноблокаторов
— одновременный прием препаратов, содержащих парацетамол
— артериальная гипертензия
— гипертиреоз
— гипертрофия предстательной железы
— беременность и период лактации
— детский возраст до 18 лет
Лекарственные взаимодействия
Препарат может усиливать эффекты ингибиторов МАО (моноаминооксидазы), трициклических антидепрессантов, седативных препаратов, этанола и этанолсодержащих препаратов.
Этанол стимулирует метаболизм парацетамола и повышает его гепатоксичность
При одновременном применении парацетамола с азидотимидином возможно развитие нейтропении.
При одновременном применении с хлорамфениколом парацетамол повышает его токсичность.
Препараты, стимулирующие активность микросомальных изоферментов, усиливают гепатотоксическое действие парацетамола.
Особые указания
В период лечения следует воздержаться от приема алкоголя, снотворных и анксиолитических (транквилизаторы) лекарственных средств. Не принимать вместе с другими лекарственными средствами, содержащими парацетамол. Если симптомы заболевания не проходят в течение 3 – 5 дней, обратиться к врачу.
Особенности влияния лекарственного средства на способность управлять транспортным средством или потенциально опасными механизмами
Следует соблюдать осторожность при выполнении работы, требующей концентрации внимания, повышенной скорости двигательных и психических реакций.
Передозировка
Симптомы: сухость во рту, учащение пульса, аритмии, потливость, тошнота, рвота, боли в животе, повышенная активность (перевозбуждение), галлюцинации, острая печеночная и/или почечная недостаточность.
Лечение: промывание желудка, внутривенное введение ацетилцистеина или метионина, симптоматическое лечение.
Форма выпуска и упаковка
По 6 таблеток (дневные) и 3 таблетки (ночные) в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной.
По 1 контурной ячейковой упаковке вместе с инструкцией по медицинскому применению на государственном и русском языках помещают в пачку из картона.
Условия хранения
Хранить в сухом, защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте!
Срок хранения
4 года
Не применять после истечения срока годности, указанного на упаковке.
Условия отпуска из аптек
Без рецепта
Название и адрес производителя
«Медлей Фармасьютикалз Лимитед», Индия
Medley House, D2, MIDS Area, Andheri (East), Mumbai – 400 093
Владелец регистрационного удостоверения
«Медлей Фармасьютикалз Лимитед», Индия
Medley House, D2, MIDS Area, Andheri (East), Mumbai – 400 093
Адрес организации, принимающей на территории Республики Казахстан претензии от потребителей по качеству продукции (товара)
Представительство компании
«Медлей Фармасьютикалз Лимитед» в РК в лице доверенного лица
Амита Шривастава
г. Алматы, ул. Курмангазы 48А
E.mail: registration1@kazeuropharm.com
Тел./факс: 261-51-41
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Национальный центр экспертизы лекарственных средств, изделий медицинского назначения и медицинской техники
Kufril syrup is an active mucolytic agent that treats coughs with mucus. Its ingredients are Ambroxol (15 mg), Levosalbutamol (0.5 mg) and Guaifenesin (50 mg). Ambroxol is a mucokinetic agent that makes the sputum thinner and easily removable by coughing.
Levosalbutamol is an adrenergic receptor antagonist that smoothes the respiratory muscles and eases air in and out of the lungs. Guaifenesin is an expectorant; it clears chest congestion. It thins the mucus in the air passageway to make it easier to cough up the mucus and decongest the chest.
It is used in the treatment of cough, acute and chronic bronchopulmonary problems, abnormal mucus secretion, chest congestion, thick mucus, constricted airways, inflammation of lungs and sore throat.
It is an anti-inflammatory and anti-oxidant anaesthetic which improves the patient’s conditions by relaxing the muscles in the airways, thinning mucus and reducing phlegm in the respiratory passage.
For adults, the usual dosage is 30 to 120 mg per day, taken twice or thrice a day, according to the doctor’s recommendation. It is usually recommended to take the syrup after food.
Kufril is used to treat the following problems:
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Cough
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Bronchospasm
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Is It safe with alcohol?
Consumption of alcohol while on this medication induces dizziness.
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Are there any pregnancy warnings?
Pregnant women must consult doctor before using this drug.
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Are there any breast-feeding warnings?
Proceed with caution, if you are breastfeeding. Discuss the benefits and risks with your physician.
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Is it safe to drive while on this medicine?
If you are suffering side-effects like headaches, drowsiness and dizziness, it is unsafe to drive.
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Does this affect kidney function?
There are no reports regarding the medicine and kidney functioning. Consult your doctor.
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Does this affect liver function?
Consult your physician about any potential risks to your liver functioning.
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How long is the duration of effect?
The effects of this syrup last for an average of 8-12 hours.
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What is the onset of action?
It takes an average of 1-2 hours to produce its effects.
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Is it habit forming?
It is not habit-forming.
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Are there any missed dose instructions?
Take the missed dose as soon as you remember. However, do not double dose.
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Are there any overdose instructions?
Consult your doctor in case of overdose.
It is an agent that causes diffusion of thick mucus. Uncontrolled quantity of nitric oxide (NO) is related to inflammation and other kinds of disruptions of the functioning of the airways. It inhibits the activation of guanylate cyclase which is nitric oxide dependent. Simultaneously, it works as a β2 adrenergic receptor that results in increase of cyclic AMP. Increased AMP leads to activation of protein kinase A which again prevents phosphorylation of myosin. All this mechanism leads to relaxation of smooth muscles. It also reduces adhesiveness and surface tension of congealed mucus in upper respiratory tract to increase flow of mucus, stimulating and increasing efficiency of the cilia to remove the accumulated mucus.
What are the interactions of Kufril LS Syrup ?
Whenever you take more than one medicine, or mix it with certain foods or beverages, you»re at risk of a drug interaction.
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Interaction with Medicine
Medicine
It interacts adversely with antibiotics, Bendroflumethiazide, Carvedilol, Nadolol, Sotalol and Timolol. These drugs change the effects of Kufril or produce severe side-effects.
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Interaction with Disease
Delete
Kufril has adverse interactions in patients with liver and kidney impairment. It is recommended to alter the dosage of the syrup for safety.
FAQs about Kufril LS Syrup
Ques: What is Kufril LS Syrup?
Ans:
It is medication which has Ambroxol, Guaiphenesin and Levosalbutamol as active elements present in it. This medication performs its action by relaxing the muscles in the airways, helps in clearing the mucus, contains anti-inflammatory, antioxidant, and also have local anaesthetic effects, restricting the phlegm in the air wawww.lybrate.com/medicine/ys.
Ques: What is the use of Kufril LS Syrup?
Ans:
This drug is used to treat cough, bronchospasm, etc.
Ques: What are the side effects of Kufril LS Syrup?
Ans:
Side effects include diarrhea, dizziness, headache, etc.
Ques: Can Kufril LS Syrup be used for cough and acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion?
Ans:
Yes, it is a medication which is used for the conditions such as cough and acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion.
Ques: How long do I need to use Kufril LS Syrup before I see improvement in my condition?
Ans:
In most of the cases, the average time taken by this medication to reach its peak effect is around 1 to 3 days, before noticing an improvement in the condition. But the same duration is not mandatory for everyone and so, it is not a standard time period for this medication’s action. Please consult your doctor, for the time period you need to consume this medication.
Ques: At what frequency do I need to use Kufril LS Syrup?
Ans:
It is generally used twice or thrice a day, as the time interval to which this medication has an impact, is around 8 to 12 hours, but it is not the standard frequency, for using this medication.
Ques: Should I use Kufril LS Syrup empty stomach, before food or after food?
Ans:
This medication is common to be taken orally and the action of salts involved in this medication, do not depend on whether taking it pre-meal or post-meal. It is advised to consult a doctor before use and take it at a fixed time in a day.
Ques: What are the instructions for the storage and disposal of Kufril LS Syrup?
Ans:
It contains salts which are suitable to store only at room temperature, as keeping this medication above or below that, can cause inadequate effect. Protect it from moisture and light. Keep this medication away from the reach of children. It is advised to dispose of the expired or unused medication, for avoiding its inadequate effect.
References
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Ambroxol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:
https://druginfo.nlm.nih.gov/drugportal/name/ambroxol
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Levalbuterol- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:
https://druginfo.nlm.nih.gov/drugportal/name/levosalbutamol
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Medicines For Cough- Drugs Bank [Internet]. drugsbanks.com. 2018 [Cited 23 April 2019]. Available from:
https://www.drugsbanks.com/medicines-for-cough/
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Guaifenesin- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2019 [Cited 23 April 2019]. Available from:
https://druginfo.nlm.nih.gov/drugportal/name/guaifenesin
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
Kufril Ls Drops
Ambroxol is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Ambroxol stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Ambroxol stimulates production of phospholipids of surfactant by alveolar cells. Ambroxol has anti-inflammatory properties. In patients with COPD, it improves airway patency. Beside these, Ambroxol also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.
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Uses
- • Acute and chronic diseases of respiratory tracts associated with viscid mucus including acute and chronic bronchitis
- • Productive cough
- • Inflammatory diseases of Rhinopharyngeal tract (e.g. Laryngitis, Pharyngitis, Sinusitis and Rhinitis) associated with viscid mucus
- • Asthmatic bronchitis, Bronchial asthma with difficult departure of mucus
- • Bronchiectasis
- • Chronic pneumonia.
Kufril Ls is also used to associated treatment for these conditions: Airway secretion clearance therapy
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How Kufril Ls works
Ambroxol is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Ambroxol has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.
Structure
Table Of contents
- Kufril Ls
- Uses
- Dosage
- Side Effect
- Precautions
- Interactions
- Uses during Pregnancy
- Uses during Breastfeeding
- Accute Overdose
- Food Interaction
- Half Life
- Volume of Distribution
- Clearance
- Interaction With other Medicine
- Contradiction
- Storage
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Dosage
Kufril Ls dosage
Average daily dose (preferably after meal):Pediatric Drops:
- 0-6 months: 0.5 ml 2 times a day
- 6-12 months: 1 ml 2 times a day
- 1-2 years: 1.25 ml 2 times a day
Syrup:
- 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
- 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
- 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.
Sustained release capsule:
- Adult and children over 12 years old: 1 capsule once daily
Specific application features: Ambroxol may be prescribed to patients suffering from diabetes mellitus.
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Side Effects
Gastrointestinal side-effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema may occur.
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Precaution
Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Interaction
Ambroxol has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Ambroxol should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Ambroxol, might not be expectorated.
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Elimination Route
Rapid and almost complete.
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Pregnancy & Breastfeeding use
Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use during pregnancy, especially in the 1st trimester.
Lactation: Safety during lactation has not been established.
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Contraindication
Contraindicated in known hypersensitivity to Ambroxol or Bromhexine.
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Innovators Monograph
You find simplified version here Kufril Ls
- Overview
- Uses
- Side-effects
- Precautions
- Interactions
- Contraindications
Overview
Kufril LS Drops is used for Cough, Acute sore throat, Asthma, Constriction of airways, Respiratory tract diseases, Colds, Lungs inflammation, Acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion, Chest congestion and other conditions. Kufril LS Drops may also be used for purposes not listed in this medication guide.
Kufril LS Drops works by relaxing the muscles in the airways; promoting mucus clearance, having anti-inflammatory, antioxidant, and local anaesthetic effects; reducing the phlegm in the air passages;
Detailed information related to Kufril LS Drops’s uses, composition, dosage, side effects and reviews is listed below.
Uses
Side-effects
Precautions
Before using Kufril LS Drops, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
- Consult doctor if condition worsens or does not improve after 14 days of use
- Consult your doctor immediately if you develop breathing difficulty, swelling on your face, neck throat or tongue
- Contact doctor immediately if experiencing allergic symptoms to this medication
- First trimester of pregnancy
- Have high blood pressure and heart disease
- If you are suffering from liver or kidney problems, or if you are taking alcohol
- If you have asthma, inflammation of air passages, lung disorder in which the flow of air to the lungs is blocked
- Indication of worsening asthma
- Inform your doctor while undergoing urine tests, if have recently taken or are taking guaifenesin as it can affect some results
- Regularly monitor blood potassium levels
Interactions with Kufril LS Drops
If you use other drugs or over the counter products at the same time, the effects of Kufril LS Drops may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Kufril LS Drops may interact with the following drugs and products:
- Antibiotics
- Bendroflumethiazide
- Carvedilol
- Nadolol
- Sotalol
- Timolol
When not to use Kufril LS Drops
Hypersensitivity to Kufril LS Drops is a contraindication. In addition, Kufril LS Drops should not be used if you have the following conditions:
- Allergic reactions
- Breastfeeding
- Breathing difficulty
- History of allergy to Ambroxol or Bromhexine
- Pregnant
- Taking more than one cough or cold medicine
Composition and Active Ingredients
Packages and Strengths
Kufril LS Drops is available in the following packages and strengths
Kufril LS Drops — Packages: 15ML Drops
Kufril LS Drops — Strengths: 0.25MG+7.5MG+12.5MG
Frequently asked Questions
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Is Kufril LS Drops safe to use when pregnant?
- Levosalbutamol: Please consult with your doctor for case-specific recommendations.
- Ambroxol: No
- Guaifenesin: No
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Is Kufril LS Drops safe while breastfeeding?
- Levosalbutamol: Please discuss the risks and benefits with your doctor.
- Ambroxol: No
- Guaifenesin: No
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Can Kufril LS Drops be used for cough and acute sore throat?
Yes, cough and acute sore throat are among the most common reported uses for Kufril LS Drops. Please do not use Kufril LS Drops for cough and acute sore throat without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Kufril LS Drops.
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How long do I need to use Kufril LS Drops before I see improvement of my conditions?
TabletWise.com website users have reported same day and within 6 hours as the most common time it takes before they saw improvements in their conditions. These times may not be reflective of what you may experience or how you should use this medicine. Please consult with your doctor to check how long do you need to use Kufril LS Drops. Click here and view survey results to find out what other patients report as time for effectiveness for Kufril LS Drops.
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At what frequency do I need to use Kufril LS Drops?
TabletWise.com website users have reported twice a day and thrice a day as the most common frequency of using Kufril LS Drops. Please follow your doctor’s advice on how often you need to Kufril LS Drops. Click here and view survey results to find out what other patients report as frequency of using Kufril LS Drops.
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Should I use Kufril LS Drops empty stomach, before food or after food?
TabletWise.com website users have most commonly reported using Kufril LS Drops before food. However, this may not be reflective of how you should use this medicine. Please follow your doctor’s advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Kufril LS Drops.
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Is it safe to drive or operate heavy machinery when using this product?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Kufril LS Drops medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Kufril LS Drops. Always consult with your doctor for recommendations specific to your body and health conditions.
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Is this medicine or product addictive or habit forming?
Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.
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Can i stop using this product immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.
Other important Information on Kufril LS Drops
Missing a dose
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
Overdosage of Kufril LS Drops
- Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Kufril LS Drops, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
- Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
- Please consult your physician or pharmacist or product package for more information.
Storage of Kufril LS Drops
- Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
- Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Kufril LS Drops.
Expired Kufril LS Drops
- Taking a single dose of expired Kufril LS Drops is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drugs. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
Dosage Information
Please consult your physician or pharmacist or refer to the product package.
Cite this page
Page URL
HTML Link
APA Style Citation
- Kufril LS Drops — Product — TabletWise.com. (n.d.). Retrieved March 27, 2023, from https://www.tabletwise.com/kufril-ls-drops
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More about Kufril LS Drops
- Uses
- Reviews
- What are the uses of Kufril LS Drops?
- What are the side-effects of Kufril LS Drops?
- What other medicines does Kufril LS Drops interact with?
- When should you not use Kufril LS Drops?
- What precautions should you take while using Kufril LS Drops?
Last updated date
This page was last updated on 9/27/2020.
This page provides information for Kufril LS Drops Product in English.
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Cough
Coughing is a reflex that keeps your throat and airways clear. …
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Sore Throat
Your throat is a tube that carries food to your esophagus and …
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Asthma
Asthma is a chronic disease that affects your airways. Your …
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Respiratory Tract
Manufactured byMed Manor Organics Pvt. Ltd.
ContainsLevosalbutamol (0.5 mg/5 ml) + Ambroxol (15 mg/5 ml) + Guaifenesin (50 mg/5 ml)
Description
Kufril-LS Expectorant is a combination of Levosalbutamol, Ambroxol and Guaifenesin.This medicine is used in relieving cough with mucous. This medicine is also used in the treatment of bronchitis, asthma, and other breathing disorders by relieving symptoms such as wheezing, shortness of breath, chest tightness, breathing difficulties, coughing, etc. Kufril-LS Expectorant dissolves thick mucous formed in the air passages and makes it easier to cough out the mucous formed in your chest. It also clears and widens your airway tubes which makes it easy for you to breathe.
Kufril-LS Expectorant shows some side effects like headache, diarrhoea, stomach upset, dizziness, nausea, vomiting, etc. Most of these are short-lasting and usually get better after some time. Talk to your doctor if these side effects bother you. This medicine may cause sleepiness, so you should avoid activities requiring mental focus like driving and operating machines.
Kufril-LS Expectorant can be taken with or without food as prescribed by your doctor. Take this medicine preferably with food to avoid any stomach problems. Drink adequate water while taking this medicine as this will help in reducing throat irritation. You should complete the whole course even if you feel better after few doses. Avoid abrupt discontinuation of this medicine as your symptoms could come back. Avoid taking this medicine for more than the prescribed duration. If a cough lasts for more than 5 days or your symptoms do not improve, consult your doctor.
Kufril-LS Expectorant should be avoided if you have an allergy to any of the known ingredients of this medicine. Inform your doctor if you have diabetes or heart, liver, stomach, and intestinal problems. Avoid giving this medicine to your child unless prescribed by your doctor. Consult your doctor if you are pregnant, or are breastfeeding.
Side effects
Major & minor side effects for Kufril-LS Expectorant
- Stomach pain
- Headache
- Sore throat and hoarseness
- Decreased appetite
- Muscle pain and cramps
- Chest pain and discomfort
- Sleep disturbances
- Difficulty in swallowing
- Nausea and Vomiting
- Diarrhoea
- Skin rash and itching
- Nervousness
- Dizziness
- Fast heartbeat
Uses of Kufril-LS Expectorant
What is it prescribed for?
- Cough with mucous
- Bronchospasm
Read More
Concerns
Commonly asked questions
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How long does it take for this medicine to take effect?
The effect of Kufril-LS Expectorant can be seen in 30 minutes after administration.
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How long do the effects of this medicine last?
It is not known how long Kufril-LS Expectorant remains active in your body.
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Is it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is this a habit forming medicine?
No habit-forming tendencies were reported for Kufril-LS Expectorant.
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Can this medicine be taken during pregnancy?
No human data is available on the use of Kufril-LS Expectorant during pregnancy. Consult your doctor.
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Can this medicine be taken while breast-feeding?
It is not known whether Kufril-LS Expectorant passes into breastmilk or not. Consult your doctor.
When not to use?
Allergy
Avoid using Kufril-LS Expectorant if you have a history of allergic to this medicine. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.
Warnings
Warnings for special population
Pregnancy
No human data is available on the use of Kufril-LS Expectorant during pregnancy. Consult your doctor.
Breast-feeding
It is not known whether Kufril-LS Expectorant passes into breastmilk or not. Consult your doctor.
General warnings
Use in Children
Kufril-LS Expectorant is not recommended in children below 12 years of age. Consult your doctor before using this medicine for your child.
Cough suppressants
Kufril-LS Expectorant is not recommended for use if you are taking cough suppressants, since they have opposite effects. Taking these medicines together may result in worsening your condition.
Driving or operating machines
Be careful while driving or operating machines after taking Kufril-LS Expectorant until you know how this medicine affects you.
Other medicines
Inform your doctor if you are taking any medications, herbs, or supplements as Kufril-LS Expectorant may interact with many other medicines.
Stomach and intestinal ulcers
Use Kufril-LS Expectorant with caution if you have a history of stomach and intestinal ulcers (painful and damaged area in the lining of the stomach) as this medicine may damage the mucosa (inner lining) of the stomach and worsen your condition.
Dosage
Missed Dose
If you forgot to take the dose of Kufril-LS Expectorant at a given time, then take it as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose
If you have consumed more than the prescribed amount of Kufril-LS Expectorant., then you might feel headache, confusion, fever, change in the heartbeat, nausea, vomiting, etc. Contact your doctor immediately for initiating overdose treatment to manage the damage.
Interactions
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Amitriptyline
Atenolol
Ketoconazole
Propranolol
Furosemide
Disease interactions
Heart Disease
The use of Kufril-LS Expectorant has been associated with an increase in heart rate and changes in blood pressure. Hence, caution should be maintained if you have a history of, or existing heart problems while using this syrup. You should not exceed the recommended dose.
Diabetes
Use this medicine with caution as there may be a slight rise in your blood sugar levels while taking Kufril-LS Expectorant. Hence, regular monitoring of blood sugar levels may be necessary.
Seizures
Use Kufril-LS Expectorant with caution if you have seizure disorders as it may increase the frequency and severity of convulsions (fits). Consult your doctor before taking the medicine.
Kidney Disease
Use Kufril-LS Expectorant with caution if you have kidney problems. An already damaged kidney will not be able to eliminate the medicine properly, thus increasing the risk of toxicity. Your doctor may adjust the dose and monitor your kidney function regularly to use this medicine safely.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
General Instructions
Take Kufril-LS Expectorant with or without food as instructed by your doctor. Drink plenty of water with this syrup as it will soothe your throat.
Shake the bottle well before use. Measure the dose of Kufril-LS Expectorant using a measuring spoon or dropper as exactly advised by your doctor. Close the cap of the container tightly after each use.
Avoid certain foods like dairy products, coffee, spicy food, etc. that can irritate your throat and produce more mucous.
Inform your doctor if you are taking any other cough and cold medicines.
Try warm saline gargle once a day as it reduces the pain and swelling in your throat. It will also help to reduce the amount of mucus at the back of your throat, lessening your need to cough.
Avoid giving this medicine to your child unless prescribed by your doctor.
Other details
Miscelleneous
Can be taken with or without food, as advised by your doctor
To be taken as instructed by doctor
May cause sleepiness
How it works
Kufril-LS Expectorant is composed of Levosalbutamol, Ambroxol and Guaifenesin.
Levosalbutamol relaxes the smooth muscles and opens the blocked air passages thereby improves the amount of airflow to the lungs and makes breathing easier.
Ambroxol causes the breakdown of mucous making the sputum thinner. Therefore, it promotes mucous clearance.
Guaifenesin makes the mucous thin in the air passages; this makes it easier to cough up the mucous and clear the airways.
Legal Status
Unknown
Unknown
Unknown
Unknown
Classification
Category
Adrenergic bronchodilators, Mucolytics, Expectorants
References
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